Grifols’ two new facilities are the latest of several expansions that are making the Clayton site one of the largest plasma-manufacturing plants in the world. In December 2017, Grifols tripled the size of its footprint there by purchasing 467 acres of land for future expansion. In July 2017, the company opened a 112,000-square-foot office building for more than 400 employees. Investments in the site between 2017 and 2022 will total about $320 million, the company said. That’s in addition to about $760 million in capital expansions between 2011 and 2017.